Intraocular Bioavailability: A Preliminary Evaluation Of An Eyedrop Instillation Technique.

A method of instilling eyedrops, the contact pool (CP) technique, was developed in pursuit of a means for enhancing the intraocular bioavailability of topically-applied medications. The topic of this paper is a pilot study evaluating the mydriatic efficacy of the CP and two other common techniques following the instillation of tropicamide. The CP technique resulted in the greatest mean increase in pupil diameter. The validity of the differences between the means of all three techniques was confirmed by the F-test; however, a small sample size strongly limits its overall significance. An expanded study in the future may provide more definitive conclusions.