Comparative Mydriasis: Temporal Spacing Of Diagnostic Pharmaceutical Agents In Pre-Presbyopes.

The rates and extent of pupillary mydriasis using three variable temporal instillation techniques were evaluated. A minimal difference in the extent of mydriasis and somewhat greater difference regarding the rate of mydriasis exist when the diagnostic pharmaceutical agents, preceeded by a topical anesthetic, are separated by thirty second, two and a half minute, and five minute intervals. The longer time interval between diagnostic pharmaceutical installations generally produces a greater amount of dilation. This difference continues up to a point, where then all evaluated techniques of instillation demonstrate approximately the same amount of mydriasis. The differences in pupillary responses have clinical usefulness in cases where the standard of care dictates pupillary dilation.