Beta Adrenegic Blocking Agents In The Treatment Of Primary Open-Angle Glaucoma.

Perhaps the most widely accepted non-invasive treatment modality for chronic open angle glaucoma is the use of beta adrenergic blocking agents(beta-blockers). Topical beta-blockers have been shown to lower intraocular pressure by decreasing the amount of aqueous produced in the ciliary processes. The exact mechanism is not known, but the effectiveness of these particular agents in controlling intraocular pressure is well documented. This paper will discuss a few of the proposed theories as to how beta-blockers induce their affect on the autonomic nervous system causing a reduction in the formation of aqueous humor. The profile of three topical beta-blockers approved for ophthalmic use in the United States will be reviewed. Finally the dissipation phenomena (short term escape or longterm drift) associated with certain beta adrenergic blocking agents will be examined.